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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: The gene can be released from the cell membrane upon activation and detected in liquid biopsy, thus offering

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 227-235 doi: 10.1007/s11684-014-0327-1

Abstract:

Accelerated senescence is important because this process is involved in tumor suppression and hasHowever, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinomaCellular senescence was then assessed by β-galactosidase assay.Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation.The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence

Keywords： reactive oxygen species     senescence     cisplatin     hepatocellular carcinoma    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract: Cellular senescence has been proposed as the mechanism that protects an organism against cancer progressionIn this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinomaThe strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectivelyCBX3 and senescence-associated β-galactosidase activity.Furthermore, Twist-induced senescence bypass is important in this process.

Keywords： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 267-276 doi: 10.1007/s11684-017-0586-8

Abstract: study aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cellsenescence and its underlying mechanism.of P16 and cyclin D1, increased senescence-associated β-galactosidase activity, and elevated expressionSKI treatment prevented HG-induced up-regulation of pro-senescence molecule mammalian target of rapamycinSKI may be a novel strategy for protecting against HG-induced renal tubular cell senescence in treatment

Keywords： Shenkang injection     senescence     renal tubular epithelial cells     diabetic nephropathy    

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Administration with

Qi RUI, Qin LU, Dayong WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 76-90 doi: 10.1007/s11684-009-0002-0

Abstract: During normal metabolism, oxidative byproducts will inevitably generate and damage molecules thereby impairing their biological functions, including the aging process. (补肾抗衰方, ) is a traditional Chinese medicine widely used for clinically treating premature ovarian failure. In the present study, administration at high concentrations significantly increased lifespan, slowed aging-related decline, and delayed accumulation of aging-related cellular damage in wild-type . administration could further largely alleviate the aging defects induced by UV and oxidative stresses, and administration at different concentrations could largely rescue the aging defects in mutant animals. The protective effects of administration on aging process were at least partially dependent on the Ins/IGF-like signaling pathway. Moreover, administration at different concentrations obviously altered the expression patterns of antioxidant genes and suppressed the severe stress responses induced by UV and oxidative stresses, suggesting that -induced tolerance to UV or oxidative stress might result from reactive oxygen species scavenging. administration during development was not necessarily a requirement for UV and oxidative stress resistance, and the concentrations of administrated examined were not toxic for nematodes. Therefore, administration could effectively retrieve the aging defects induced by UV irradiation and oxidative stress in .

Keywords： Bushenkangshuai Tang     UV irradiation     oxidative stress     tissue senescence     lifespan        

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 90-98 doi: 10.1007/s11705-015-1550-2

Abstract: The well-designed microscale intermediary is also ideal for the study of cell biology.Particularly, microfluidic chip is helpful for better understanding cell-cell interactions.

Keywords： microfluidic chip     co-culture     cell-cell interactions     review    

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine   Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cellMNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cellThese MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting

Keywords： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing    

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Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 451-462 doi: 10.1007/s11684-018-0651-y

Abstract: Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential

Keywords： deubiquitinase     ubiquitination     T cell activation     T cell differentiation     T cell tolerance    

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Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 46-57 doi: 10.1007/s11705-017-1609-3

Abstract: Cell surface protein engineering facilitated by accumulation of information on genome and protein structureinvolves heterologous production and modification of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts.In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a carrier protein.

Keywords： cell surface engineering     surface display     whole-cell catalysts     bioprocess    

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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract: Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords： stem cell     stem cell niche     electric field     tissue repair    

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-cellthe causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell

Keywords： CAR T cells     hematological malignancies     review    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords： ALDOB     kidney cancer     cell proliferation    

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: notwithstanding, hundreds of companies and private clinics around the world now sell putative stem cellIn this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism     medical ethics     stem cell policy and regulation     alternative medicine    

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Fine-tuning cell organelle dynamics during mitosis by small GTPases

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 339-357 doi: 10.1007/s11684-022-0926-1

Abstract: coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression, cellSmall GTPases belonging to the Ras superfamily regulate various cell organelles during division.the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associated with cellThis review collects current knowledge on small GTPases in the regulation of cell organelles during mitosisand highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics

Keywords： small GTPase     cell organelle     mitosis    

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Title Author Date Type Operation

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Administration with

Qi RUI, Qin LU, Dayong WANG

Journal Article

Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Journal Article

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Journal Article

Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Journal Article

Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Journal Article

CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Journal Article

Fine-tuning cell organelle dynamics during mitosis by small GTPases

Journal Article